Saturday, 25 October 2014

PROF JUDITH MIKLOSSY DISCUSSES LYME BORRELIOSIS AND ALZHEIMER'S @ NORVECT CONFERENCE 2014




Prof. Judith Miklossy held a very interesting presentation at the NorVect Conference 2014. In particular she looked at the connection between Lyme disease and Alzheimer´s disease. Here is an excerpt. All presentations from the NorVect conference can be watched in full length at www.norvect.no

All 14 excerpts can be viewed  https://www.youtube.com/channel/UCn3zx5pQ9_szEkWdAdXoyTw 

NORVECT website http://norvect.no/about-norvect/

Speakers http://norvect.no/conference-2015/norvect-conference-2014/

For just under £15 you can buy access to the full presentations from Norvect
 
For more information about Prof Judith Miklossy's research work visit her website http://miklossy.ch/

Tuesday, 21 October 2014

BORRELIOSIS - LYME DISEASE'S KNOWN INVOLVEMENT WITH MENTAL HEALTH


Scientists and physicians across the world have discovered that the growing numbers of people with mental illness and diseases of the nervous system are being cured or improved by treatment with antibiotics. In other words, it is now known that bacteria can make you mentally ill as well as physically ill!

From Croatia to California, from Sweden to Sicily, conditions such as Schizophrenia and Multiple Sclerosis, even Alzheimer's disease and Stroke, are being found to have common to all one of the most insidiously infective bacteria on the planet, namely Borrelia.

This organism is similar to the bacterium that causes Syphilis, which was once the major cause of mental ill health before the days of penicillin. Both bacteria are large and spiral in shape, but Borrelia is turning out to be far worse than its cousin. Syphilis could be detected fairly easily and then killed with antibiotics, but Borrelia is harder to find, and then it is even more difficult to eradicate. Because it causes such a wide range of symptoms, from mild 'flu-like fever to a rapid onset of psychosis, or from strange rashes to sudden heart-block, this nasty bacterium has spread without most of us realising it, around the world, in what is now being called a pandemic.

Perhaps its most miserable victims are those with hallucinations, panic disorders, manic depressive illness and ADHD, as well as those with the labels of Chronic Fatigue Syndrome and Myalgic Encephalomyelitis; for although the latter two conditions are recognised to be of a bacterial / viral cause by the World Health Organisation, the British medical establishment employees predominantly psychological intervention alone. Imagine being confined to a secure mental hospital, or treated with powerful antipsychotic drugs, or living for decades struggling to maintain normal memory and behaviour patterns,when all along there has been an infection secretly living in your brain and nerves. This bacterium may sometimes be the cause of anorexia, while in some of its victims it has been known to cause episodes of uncontrollable rage.

Other bacteria and viruses can wreak similar havoc: some of the ones that live harmlessly in our throats and on our skin are also able to invade our brains. Doctors and scientists are quite ready to acknowledge and search for things like HIV, Streptococcus and Herpes.But it is only recently that they are becoming aware that the Borrelia bug, one of the hardest to positively identify because of its so-called "stealth " behaviour, must be high on the list for diagnosis.
European countries such as Austria, Germany, Holland and France, have alerted their GPs and specialists to the growing problem of Borrelia. Germany has twice polled every doctor in the country to determine the probable infection rate, and has found that it has doubled in the last 10 years. The Dutch have carried out similar surveys. In Austria, every GP's waiting room has warning signs about Borreliosis.The disease is being spread by ticks that are carried on birds, on wild animals and on pets such as cats and dogs, even on horses. It has been found inside the stomachs of biting flies such as horseflies and cleggs and also in mosquitoes and mites.

We present here several medical studies published in recent literature,which link mental illness and brain disease to known Borreliosis infection. There were few to be found that had been carried out in Britain; those quoted here are from the rest of Europe and the United States.

a)In a controlled study undertaken at Columbia University Department of Psychiatry, 20 children were examined following known infection of Borrelia burgdorferi (Bb), and were found to have significantly more psychiatric and cognitive difficulties. Their cognitive abilities were found to be below that of 20 matched healthy control subjects,even taking into account any effects due to anxiety, depression and fatigue during education. The study also discussed the long-term effects of the children’s infection with Borrelia, which had brought about neuropsychiatric disturbances and caused significant psychosocial and academic impairment.

b)An elderly lady treated at the Emperor Franz Josef hospital, Vienna,was initially admitted with suspected Motor Neuron Disease. Testing of fluid from her spinal column indicated the presence of Bb.Following antibiotic treatment, improvement was seen in the patient’s clinical symptoms, and further testing of spinal fluid demonstrated a positive response to the antibiotic treatment. The preliminary diagnosis of amyotrophic lateral sclerosis (ALS) was revised to one of chronic neuroborreliosis, the term given to infection of the central nervous system (CNS) by Bb.

c) A 64-year old woman was admitted to the psychiatric ward of the Sophia Ziekenhuisat Zwolle, in Holland. She was suffering from psychosis, with visual hallucinations, disorientation in time and space, and associative thinking. Psychotropic drugs failed to produce any improvement in her condition and further, neurological, symptoms developed. A lumbar puncture revealed the presence of Borrelia burgdorferi and after treatment with penicillin all of her psychiatric and neurological symptoms were resolved. From the history, which the woman was then able to communicate, it appeared she had been bitten by ticks. Her husband, aged 66, passed through a similar episode of disease

d)In a comparative study carried out at the Prague Psychiatric Center,the blood of 926 psychiatric patients and that of 884 healthy control subjects was screened for four different types of antibodies to Borrelia burgdorferi. Of 499 matched pairs (meaning of similar age and gender but from patient and control group respectively) 166 (33%)of the psychiatric patients and 94 (19%) of the healthy comparison subjects were seropositive in at least one of the four test assays for Bb. This study supports the hypothesis that there is an association between an infection of Borrelia burgdorferi and psychiatric morbidity.

e)It has been well documented in numerous published medical studies of Borrelia's ability to cause many recognized personality disorder sand forms of depression; such as anxiety, depression, confusion,aggressive behaviour, mild to moderate cognitive deficits,fatigue,memory loss, and irritability. As such, the American Psychiatric Associations recommends that specialist doctors and counselors alike should seek to rule out Borreliosis as a possible differential diagnosis before commencing with any form of psychological intervention.

f)At the University of Rostock in Germany, a 42-year old female patient presented with schizophrenia-like symptoms but a complete lack of neurological signs. A brain scan and investigation of the spinal fluid led to the diagnosis of Lyme disease. There was complete relief of symptoms after antimicrobial therapy.

g)In a study of patients at a Boston, MA, hospital, scientists looked at patients with a history of Lyme disease who had been treated with short courses of antibiotics. As well as many physical symptoms, such as musculoskeletal impairment, the Lyme sufferers were found to have highly significant deficits in concentration and memory. Those who had received treatment early in the course of the illness had less long-term impairment.

h)At the Kanazawa University School of Medicine in Japan, a 36-year old woman with severe chronic Encephalomyelopathy was shown to have a very high level of antibodies to Borrelia burgdorferi. She showed severe cerebellar ataxia (walking and balance difficulties due to disease in the cerebellum) and profound mental deterioration. The disease had probably been acquired while she had been in the USA. The autopsy 4 years later showed the presence of spirochaetes throughout the brain and spinal cord, which together with the antibody evidence,demonstrated that the Lyme bacteria had caused this encephalitic form of neuroborreliosis.

i)Dr B. A. Fallon and his team at Columbia University Medical Centre in New York have done extensive studies on both adults and children with Lyme disease. They describe numerous psychiatric and neurological presentations of the disease, and show that it can mimic attention deficit hyperactivity disorder (ADHD), depression and multiple sclerosis. In another study, the same team found panic disorder and mania could be caused by Borrelial infection.  

j)Scientists from Vancouver, Canada, and Lausanne, Switzerland,recently looked at post-mortem brain tissue samples from 14 patients who had had Alzheimer’s disease and compared them with 13 controls.All of the Alzheimer’s brains had infection with Borrelia-type organisms, compared to none of the controls. From 3 of the Alzheimer’s cases, they were able to carry out genetic and molecular analyses of these spirochaetes to prove beyond a doubt that they were Borrelia.

k)Following the detailed statistical analysis of all published literature on schizophrenia, (with the criterion that each study had to have detailed histories for at least 3000 patients), Swiss scientist Dr Mark Fritzsche was able to demonstrate that: "globally there is a striking correlation between seasonal and geographical clusters of both Multiple Sclerosis and Schizophrenia with the worldwide distribution of the Lyme bacteria." Yearly birth-excesses of such illnesses were found to mirror, with an intervening nine-month period, both the geographical and seasonal patterns of various types of Ixodes tick. He also went on to further state “In addition to known acute infections, no other disease exhibits equally marked epidemiological clusters by season and locality, nurturing the hope that prevention might ultimately be attainable.”

l)Chronic fatigue syndrome has been found to be associated with infection by Borrelia. A study by the Department of Neurology at the University Hospital of Saarland in Homburg, Germany, investigated blood samples from 1,156 healthy young males, without knowing which ones were suffering from CFS. They saw a significant number with CFS sufferers who had Borrelia antibodies even though there were no other signs of borreliosis symptoms. They state that antibiotic therapy should be considered in patients with Chronic Fatigue Syndrome who show positive Borrelia serology.

m)Dr R. C. Bransfield in New Jersey, has found a significant number of Lyme patients exhibit aggression. Patients were described with decreased frustration tolerance, irritability, and some episodes of explosive anger which he terms “Lyme rage”. In relatively rare cases, there was uncontrollable rage, decreased empathy,suicidal tendencies, suicide, homicidal tendencies, interpersonal aggressiveness, homicide and predatory aggression.

The World Health Organisation has warned that mental illness appears to be increasing globally, and that depression will soon become the second biggest cause of disease on the planet. In Britain, it is estimated that new-onset psychoses have reached the annual level of 30 per 100,000 of the population. According to recent announcements,although there are at present about 900 consultant psychiatrists employed in the UK, with 400 posts vacant, there are plans to recruit 7,500 new psychiatrists in the next 5 years, a massive 5-fold increase.

The European Committee for Action on Lyme Borreliosis (EUCALB) has published epidemiological studies showing that there is a serious problem with tick-borne Borreliosis in Europe. For example, the UK’s nearest neighbour, Holland, has found 73 cases per 100,000 of the population per year, with an unknown number of missed diagnoses. The published figures for England, Ireland and Wales appear to be nearly2 orders of magnitude lower than this, with only 0.3 cases per 100,000. Are cases of Lyme disease / Borreliosis not being found in Britain because it is still regarded as a rare disease in this country? Or do we genuinely have the lowest incidence in the world? Diagnosis of borreliosis is difficult, with tests for antibodies to the bacteria being the subject of great controversy at present. If a consultant has to look at a suspected case of the disease and believes it to be rare, and blood tests are unreliable, then the diagnosis will be biased, quite understandably, towards the patient having some other condition.

It is hoped that health professionals at all levels, and in all disciplines, will come to realise that Human Borreliosis is the fastest-growing, most prevalent zoonotic disease in the world, and has been called a modern pandemic by several authors, including epidemiologists, rheumatologists, neurologists and infectious disease experts. There seems to be little awareness in the UK at present about this situation, but we urge that it be recognised sooner rather than later, in the hope that both mental and physical illnesses due to Borrelia are successfully diagnosed and treated.

References

a) A Controlled Study of Cognitive Deficits in Children
with Chronic Lyme disease.
Tager, F.A., Fallon, B.A., Keilp, J.,Rissenberg, M., Jones, C.R.,
Liebowitz,M.R.
JNeuropsychiatry Clin. Neurosci. 2001; Fall; 13(4): 500-7.

b) ALS-Like Sequelae in Chronic Neuroborreliosis.
Hansel,Y., Ackerl, M., Stanek, G.
Wien. Med. Wochenschr. 1995; 145(7-8):186-8.

c) Lyme Psychosis.
vanden Bergen, H.A., Smith, J.P., van der Zwan, A.
Ned.Tijdschr. Geneeskd. 1993; 137(41): 2098-100.

d) Higher Prevalence of Antibodies to Borrelia burgdorferi in Psychiatric Patients than in Healthy Subjects.
Hajek, T., Paskova, B.,Janovska, D., Bahbouh, R., Hajek, P., Libiger, J., Hoschl, C.
Am.J. Psychiatry 2002; 159(2): 297-301.

e) Highlights of the 2000 Institute on Psychiatric Services
Guardiano,J.J., von Brook, P.
Jan.2001, 52(1): 37-42.

f) Borrelia burgdorferi Central Nervous System Infection
Presenting as Organic Psychiatric Disorder.
Hess,A., Buchmann, J., Zettel, U.K., et al.
Biol.Psychiatry 1999; 45(6): 795.

g) The Long-term Clinical Outcomes of Lyme disease. A Population-based Retrospective Cohort Study.
Shadick,N.A., Phillips, C.B., Logigian, E.L., Steere, A.C. et al.
Ann.Intern. Med. 1994; 121(8): 560-7.

h) Borrelia burgdorferi Seropositive Chronic Encephalomyelopathy: Lyme Neuroborreliosis? An Autopsied Report.
Kobayashi, K., Mizukoshi,C., Aoki, T., Muramori, F.et al.
Dement. Geriatr. Cogn. Disord.1997; 8(6): 384-90.

i) (1) Late Stage Neuropsychiatric Lyme Borreliosis.
Fallon,B.A., Schwartzburg, M., Bransfield, R., Zimmerman, B. et al.
Psychosomatics1995; 36(3): 295-300
(2) Functional Brain Imaging and Neuropsychological Testing in Lyme Disease.
Fallon,B.A., Das, S., Plutchok, J.J., Tager, F. et al.
Clin.Infect. Dis. 1997; Suppl.1: 557-63.

j) Borrelia burgdorferi Persists in the Brain in Chronic Lyme
Neuroborreliosis and may be associated with Alzheimer disease.
Miklossy,J., Khalili, K., Gern, L., Ericson, R.L., et al.
J.Alzheimer’s Dis. 2004; 6(6): 639-649.

k) (1) Chronic Lyme Borreliosis at the root of Multiple Sclerosis - is a cure with
Antibiotics attainable?
Fritzsche,M.
MedHypotheses 2005; 64(3): 438-48.
(2)Geographical and Seasonal Correlation of Multiple Sclerosis to Sporadic
Schizophrenia.
Fritzsche,M.
Int.J. Health Geog. 2002; 1: 5.

l) Chronic Fatigue Syndrome in Patients with Lyme Borreliosis.
Treib,J., Grauer, M.T., Haas, A., Langenbach, J. et al.
Eur.Neurol. 2000;  43(2): 107-9.

m) Aggression& Lyme disease.
Bransfield,R.C.
14th International Scientific Conference on Lyme Disease and other Tick-borne Disorders.April 22-23, 2001, Hartford, Connecticut.

Sunday, 19 October 2014

CHRONIC ILLNESS FOLLOWING TICK BITE - LYME DISEASE?

Many people have the experience of falling into a chronic illness following a known Tick Bite/s although Only 40-50% of patients can recall a tick bite. (1)

Not everyone gets a Bulls Eye or Erythema Migrans rash although it is diagnostic of Lyme Disease, erythema migrans - may be absent in up to 30% of cases (1)

The usual NHS tests used for Borrelia ( Lyme Disease) are two tier antibody tests, there are acknowledged limitations to these tests. (2)
a) indirect - measure of immune response and not current infection
b) do not include all known species or strains
c) dependent on a person's immune response antibiotics, steroids or immune problems can affect response.
d) Undulatory immune response can affect test results.
e) Interpretation of bands and actual bands reported on.

There are better testing methods that are sometimes used in a research situation, proteomics (3) and several blood microscopy and culture methods described which could be researched further and utilised in the UK. (4)

Ticks are known to carry a soup of microbes (5) many of which are known to cause human health problems there is no research into the synergistic way these infections can work once infecting the human host.

Testing is limited for Tick borne infections and may not be sufficiently sensitive for different strains of Babesia, Bartonella as well as Borrelia. (6)

Without good testing then clinical diagnosis is what we are left with. Currently there is little experience within the NHS to diagnose a late or chronic stage of Lyme Disease using a clinical diagnosis - most NHS doctors dismiss Chronic Lyme disease out of hand due to historic misinformation (7) - current guidance was found to have many uncertainties by James Lind Alliance research - Dept of Health and HPA(PHE) over saw that research. (8)

Science moves on but medicine is slow to acknowledge change and patients suffer.

CDC are at last discussing persistence of Borrelia - (9)

Dr Stephen Barthold NIH researcher of 25 years with Borrelia in animals says '100% of animals remain infected after antibiotics - Borrelia persists as the rule not the norm'  (10)

Many studies acknowledge persistence of Borrelia in humans. (11) 

Johns Hopkins recently studied Borrelia persistence in vitro using standard FDA drugs (12) -  about 70% persister cells found after antibiotics used for treating Lyme Disease. (13)

One huge stumbling block to treating patients on longer courses of antibiotics is attitude and concerns over antibiotic resistance. However this needs to be considered more carefully in the light of Prof Kim Lewis work. He believes the problem is not resistance but persistence and has researched E Coli, MRSA, TB and  Pseudonyms finding a compound that helps deal with the persister cells. His three videos are very informative. (14 )

Prof Lewis has been given a grant to research into persister cells in Borrelia he has already found that the compound that works with MRSA does not work on Borrelia persisters. (15)


I saw doctors with Bites Erythema Migrans rashes, Summer flu, migrating arthralgias and yet it took 5 doctors and 3 Rheumatologists 4 years to diagnose me. As my health deteriorated I was diagnosed with Fibromyalgia, ME/CFS, Musculo skeletal Disease, Polymyalgia Rheumatica - a chance course of antibiotics improved my symptoms of joint pain and muscle weakness and led GP to consider Lyme Disease ( there had been other cases infected locally) my records confirmed my history. My NHS and private tests were negative but I'd been given 20 months of steroids for wrong diagnosis as well as antibiotics both could have skewed the test results. With the help of a private doctor and an open minded GP  I was treated empirically on many many months of antibiotics - my GP could see my response and recovery on antibiotics and decline when antibiotics stopped. I had been retired early on ill health grounds from the Civil Service, at my worst I struggled to raise from a chair or walk across a room I was unable to climb up or down stairs properly for 3 1/2 years now I am much recovered and can climb stairs, cycle and live a normal pain free life.
I was fortunate.

In the light of so many uncertainties and lack of adequate testing, patients who are sick and need help now read the research papers and some are fortunate to get treatment. However the vast majority are refused antibiotics by NHS doctors based on  misinformation. If antibiotics are found to help improve the patients condition then doctors could treat empirically informing the patient of the possible adverse effects. Patients should be allowed choices in their care.










(10) US Congressional Hearing on Lyme Disease -Dr Barthold at 53 mins in

(11) a- Phillips, S. (2012). Active infection: Clinical definitions and evidence of persistence in Lyme disease- Contesting the underlying basis for treatment limitations for early and late Lyme disease, as well as chronic Lyme disease, alternatively known as “Post-Lyme disease syndrome.”
 b- Barbour, A. (2012). Remains of Infection. Journal of Clinical Investigation, 122(7), 2344-2346.
 c- Lin, X., McHugh, A., Damle, N., Sikand, V., Glickstein, L., Steere, A. (2011). Burden and viability of Borrelia burgdorferi in skin and joints of patients with Erythema migrans or Lyme arthritis. Arthritis and Rheumatism, 63(8),2238-2247.

d- Schmidli, J., Hunzicker, T., Moesli, P. (1988). Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy

due to Lyme borreliosis. Journal of Infectious Diseases, 158, 905-906.
e- Haupl, T., Hahn, G., Rittig, M., Krause, A., Schoerner, C., Schonherr, U., … Burmester, G. (1993). Persistence of B. burgdorferi in ligamentous tissue from a patient with chronic Lyme borreliosis. Arthritis and Rheumatism, 36, 1621-1626.



(14) a. The Paradox of Chronic Infections 
       b.The Principles of antibiotic Discovery 
       c.Uncultured Bacteria https://www.youtube.com/watch?v=-ojRvlwanSA


Sunday, 24 August 2014

AUTISM, VACCINATION, MMR, FRAUD AND SOME LYME DISEASE INFORMATION

This is copied from Dr Robert Bransfield's Facebook page but much of the content is being shared on Facebook from many sources.

CDC Fraud Exposed
The trade marked phrase of the CDC is “Saving Lives, Protecting People” however failures within the CDC have resulted in a number of major failures such as biohazard lab failures, the high titer Edmonston-Zagreb measles vaccine studies and the financially biased and scientifically unsound reliance upon the poor quality two tiered Lyme disease testing.
A recent peer reviewed article by BS Hooker demonstrates the concerns about the MMR vaccine noted by Andrew Wakefield had scientific validity and the attempts to discredit him had not scientific merit. The article is called: Measles-mumps-rubella vaccination timing and autism among young African American boys: a reanalysis of CDC data and is posted on MedLine at: http://www.ncbi.nlm.nih.gov/pubmed/25114790 A vide expanding upon the issues is at:http://vimeo.com/user5503203/review/103711143/91f7d3d4d8 Since the video has been released it has started a firestorm of controversy:http://www.foiacentre.com/news-MMR-070305_2.htmlhttp://jonrappoport.wordpress.com/2014/08/22/breaking-cdc-whistleblower-thompson-in-grave-danger-now/ We need better safeguards to prevent current CEDC fraud. It currently exists in regard to Lyme disease and a thorough investigation is needed.
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I copy the NIH study below
Transl Neurodegener. 2014 Aug 8;3:16. doi: 10.1186/2047-9158-3-16. eCollection 2014.

Measles-mumps-rubella vaccination timing and autism among young african american boys: a reanalysis of CDC data.

Abstract

BACKGROUND:

A significant number of children diagnosed with autism spectrum disorder suffer a loss of previously-acquired skills, suggesting neurodegeneration or a type of progressive encephalopathy with an etiological basis occurring after birth. The purpose of this study is to investigate the effectof the age at which children got their first Measles-Mumps-Rubella (MMR) vaccine on autism incidence. This is a reanalysis of the data set, obtained from the U.S. Centers for Disease Control and Protection (CDC), used for the Destefano et al. 2004 publication on the timing of the first MMR vaccine and autism diagnoses.

METHODS:

The author embarked on the present study to evaluate whether a relationship exists between child age when the first MMR vaccine was administered among cases diagnosed with autism and controls born between 1986 through 1993 among school children in metropolitan Atlanta. The Pearson's chi-squared method was used to assess relative risks of receiving an autism diagnosis within the total cohort as well as among different race and gender categories.

RESULTS:

When comparing cases and controls receiving their first MMR vaccine before and after 36 months of age, there was a statistically significant increase in autism cases specifically among African American males who received the first MMR prior to 36 months of age. Relative risks for males in general and African American males were 1.69 (p=0.0138) and 3.36 (p=0.0019), respectively. Additionally, African American males showed an odds ratio of 1.73 (p=0.0200) for autism cases in children receiving their first MMR vaccine prior to 24 months of age versus 24 months of age and thereafter.

CONCLUSIONS:

The present study provides new epidemiologic evidence showing that African American males receiving the MMR vaccine prior to 24 months of age or 36 months of age are more likely to receive an autism diagnosis.

KEYWORDS:

Autism; Measles-mumps-rubella (MMR) vaccine 

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Just recently this was published 

Med Hypotheses. 2014 Jun 16. pii: S0306-9877(14)00233-3. doi: 10.1016/j.mehy.2014.06.005. [Epub ahead of print]

Divergent opinions of proper Lyme disease diagnosis and implications for children co-morbid with autism spectrum disorder.

Abstract

This paper proposes that some children with an autism spectrum disorder (ASD) in the United States have undiagnosed Lyme disease and different testing criteria used by commercial laboratories may be producing false negative results. Two testing protocols will be evaluated; first, the Centers for Disease Control (CDC) and Infectious Disease Society of America (IDSA) approved two-tiered Enzyme Immunoassay (EIA) or Immunofluorescence Assay (IFA) followed by an IgM and/or IgG Western Blot test. Second, a clinical diagnosis (flu like symptoms, joint pain, fatigue, neurological symptoms, etc.) possibly followed by a Western Blot with a broader criteria for positive bands [1]. The hypothesis proposes that the former criteria may be producing false negative results for some individuals diagnosed with an ASD. Through an online survey parents of 48 children who have a diagnosis of an ASD and have been diagnosed with Lyme disease were asked to fill out the Autism Treatment Evaluation Checklist (ATEC) before they started antibiotic therapy and after treatment. Of the 48 parents surveyed 45 of them (94%) indicated their child initially tested negative using the two-tiered CDC/IDSA approved test. The parents sought a second physician who diagnosed their child with Lyme disease using the wider range of Western Blot bands. The children were treated with antibiotics and their scores on the ATEC improved. Anecdotal data indicated that some of the children achieved previously unattained developmental milestones after antibiotic therapy began. Protein bands OSP-A and/or OSP-B (Western Blot band 31) and (Western Blot band 34) were found in 44 of 48 patients. These two bands are so specific to Borrelia burgdorferi that they were targeted for use in vaccine trials, yet are not included in the IDSA interpretation of the Western Blot.
Copyright © 2014. Published by Elsevier Ltd.

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and also interesting to hear Dr Jones Interview where he also discusses Lyme and Vaccination  in Autistic children too long to copy

Saturday, 2 August 2014

GUIDELINES FOR LYME DISEASE

New Standard of Care Guidelines for Treating Lyme and Other Tick-borne Illnesses Released by International Lyme and Associated Diseases Society (ILADS)

Bethesda, Maryland, July 31, 2014
How doctors treat patients with suspected Lyme infections needs to change so as to avoid potential long term illness and suffering.  To that end, the International Lyme and Associated Diseases Society (ILADS) today released updated guidelines for the treatment of Lyme and other tick borne infections which call on physicians to provide evidence-based, patient-centered care for those with Lyme disease.
 
Published in the August 2014 edition of the journal Expert Review of Anti-infective Therapythe new guidelines, titled: Evidence Assessments and Guideline Recommendations in Lyme disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease, say current antibiotic protocols used by many physicians to prevent or treat Lyme disease are inadequate, leading to an increased risk of Lyme disease developing into a chronic illness.
 
“Chronic manifestations of Lyme disease can continue long after other markers of the disease, such as the erythema migrans rash, have resolved,” said Daniel Cameron, M.D., M.P.H., and lead author. “Understanding this reality underlies the recommendation for careful follow-up to determine which individuals with Lyme disease could benefit from additional antibiotic therapy.”
 
 ILADS is the first organization to issue guidelines on Lyme disease which comply with the standards set by the Institute of Medicine for developing trustworthy protocols. The document provides a rigorous review of the pertinent medical literature and contains recommendations for Lyme disease treatment based on the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) process. This review format is used by other well-respected medical organizations including the Cochrane Collaboration and the World Health Organization.
 
ILADS’ GRADE-based analyses discovered research studies guiding current treatment protocols were of very low quality; and, the regimens based on these randomized controlled trials often failed.  “For this reason, we moved away from designating a fixed duration for antibiotic therapy for tick borne illnesses and instead encourage clinicians to tailor therapy based on the patient’s response to treatment,” noted Dr. Cameron.
 
“We not only recommend clinicians perform a deliberate and individualized assessment of the potential risks and benefits of various treatment options before making their initial selection,”  said guidelines coauthor Elizabeth Maloney, M.D., “we also recommend careful follow-up. Monitoring a patient allows clinicians to adjust therapy as circumstances evolve. This more selective approach should reduce the risk of inadequate treatment giving rise to a chronic illness,” added Dr. Maloney.
 
The guidelines encourage shared medical decision making and taking patient values into consideration. Lorraine Johnson, J.D., MBA, a coauthor and Executive Director of LymeDisease.org, noted, “A lot of the treatment decisions in Lyme disease depend on trade-offs. How sick is the patient? How invasive is the treatment? What is valued by the patient? Patients need to understand the risks and benefits of treatment options to make informed medical choices,” added Ms. Johnson. “These guidelines provide that information.”
 
 
 
ILADS is a nonprofit, international, multidisciplinary medical society dedicated to the appropriate diagnosis and treatment of Lyme and associated diseases.
 
 
For more information:
 
www.ilads.org
 
Facebook
Further article on Lyme Disease.org 
ABSTRACTSection:
Next section
Evidence-based guidelines for the management of patients with Lyme disease were developed by the International Lyme and Associated Diseases Society (ILADS). The guidelines address three clinical questions – the usefulness of antibiotic prophylaxis for known tick bites, the effectiveness of erythema migrans treatment and the role of antibiotic retreatment in patients with persistent manifestations of Lyme disease. Healthcare providers who evaluate and manage patients with Lyme disease are the intended users of the new ILADS guidelines, which replace those issued in 2004 (Exp Rev Anti-infect Ther 2004;2:S1–13). These clinical practice guidelines are intended to assist clinicians by presenting evidence-based treatment recommendations, which follow the Grading of Recommendations Assessment, Development and Evaluation system. ILADS guidelines are not intended to be the sole source of guidance in managing Lyme disease and they should not be viewed as a substitute for clinical judgment nor used to establish treatment protocols.

Monday, 21 July 2014

ALZHEIMER CAUSED BY SPIROCHETES - SYPHILIS, BORRELIOSIS (LYME DISEASE), DENTAL PATHOGENS




Alzheimer Borreliosis Lecture London June 4 2014
Dr Alan MacDonald 


Published on Jul 17, 2014
Infection Induced Human Dementias are briefly reviewed,.Tertiary Syphilitic 
Dementia ( General Paresis) is reviewed and comparisons with Tertiary Spirochetal Human infections , dementing types. (Leptospirosis-NEJM 2014, Treponema pallidum, Borrelia burgdorferi family of spirochetes, and other Oral Treponemes.
The Conclusion Formulation by Dr. Alan MacDonald, MD is that
Alzheimer's disease of the Subtype caused by Tertiary Neuroborreliosis
demonstrates Evidence by Borrelia specific DNA Probe analysis and by 
Microbiologic cultures of Autopsy Alzheimer's Brain tissues producing
live Borrelia in pure culture, that Alzheimer's of the Tertiary Borreliosis type
is a infectious disease. The Plaques in such cases are Borrelia biofilm communities.
Granular Vacuolar lesions of the Hippocampus are granular borrelia
which contain Borrelia DNA and which Bind Borrelia specific DNA tissue
probes with In Situ DNA Hybridization in Autopsy studies.
The Borrelia infection subtype of Alzheimer's, in like manner with with
Treponema pallidum induced Dementia in late disease has the potential to to
be cured by antibiotic therapies. 

The above lecture was given at the Inaugural Meeting of the Spirochetal Alzheimer Association link here

Friday, 18 July 2014

BORRELIA MIYAMOTOI FOUND IN TICKS IN ENGLAND

Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England.

Link to the paper on Pubmed here  

 2014 Jul 14:1-9. [Epub ahead of print]

Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England.

Abstract

SUMMARY This paper reports the first detection of Borrelia miyamotoi in UK Ixodes ricinus ticks. It also reports on the presence and infection rates of I. ricinus for a number of other tick-borne pathogens of public health importance. Ticks from seven regions in southern England were screened for B. miyamotoi, Borrelia burgdorferi sensu lato (s.l.), Anaplasma phagocytophilum and Neoehrlichia mikurensis using qPCR. A total of 954 I. ricinus ticks were tested, 40 were positive for B. burgdorferi s.l., 22 positive for A. phagocytophilum and three positive for B. miyamotoi, with no N. mikurensis detected. The three positive B. miyamotoi ticks came from three geographically distinct areas, suggesting a widespread distribution, and from two separate years, suggesting some degree of endemicity. Understanding the prevalence of Borrelia and other tick-borne pathogens in ticks is crucial for locating high-risk areas of disease transmission.
PMID:
 
25017971
 
[PubMed - as supplied by publisher] 
  

Borrelia miyamotoi found in ticks in England is of significant importance because of problems over testing

Lyme Disease Action  discusses Borrelia Miyamotoi in this article here 

Illness following Tick bites may not always be identified by blood tests, essentially 
doctors may have to make a clinical diagnosis and treat empirically 

An excellent source of information for clinicians and patients is Lyme Disease Action