Sunday, 25 June 2017


Thanks to Dr Robert Bransfield for this important work published 16th June 2017

Video abstract of original research paper “Suicide and Lyme and associated diseases” published in the open access journal Neuropsychiatric Disease and Treatment by Bransfield RC

Purpose: The aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD). No journal article has previously performed a comprehensive assessment of this subject.

Introduction: Multiple case reports and other references demonstrate a causal association between suicidal risk and LAD. Suicide risk is greater in outdoor workers and veterans, both with greater LAD exposure. Multiple studies demonstrate many infections and the associated proinflammatory cytokines, inflammatory-mediated metabolic changes, and quinolinic acid and glutamate changes alter neural circuits which increase suicidality. A similar pathophysiology occurs in LAD.

Method: A retrospective chart review and epidemiological calculations were performed.

Results: LAD contributed to suicidality, and sometimes homicidality, in individuals who were not suicidal before infection. A higher level of risk to self and others is associated with multiple symptoms developing after acquiring LAD, in particular, explosive anger, intrusive images, sudden mood swings, paranoia, dissociative episodes, hallucinations, disinhibition, panic disorder, rapid cycling bipolar, depersonalization, social anxiety disorder, substance abuse, hypervigilance, generalized anxiety disorder, genital–urinary symptoms, chronic pain, anhedonia, depression, low frustration tolerance, and posttraumatic stress disorder. Negative attitudes about LAD from family, friends, doctors, and the health care system may also contribute to suicide risk. By indirect calculations, it is estimated there are possibly over 1,200 LAD suicides in the US per year.

Conclusion: Suicidality seen in LAD contributes to causing a significant number of previously unexplained suicides and is associated with immune-mediated and metabolic changes resulting in psychiatric and other symptoms which are possibly intensified by negative attitudes about LAD from others. Some LAD suicides are associated with being overwhelmed by multiple debilitating symptoms, and others are impulsive, bizarre, and unpredictable. Greater understanding and a direct method of acquiring LAD suicide statistics is needed. It is suggested that medical examiners, the Centers for Disease Control and Prevention, and other epidemiological organizations proactively evaluate the association between LAD and suicide.

Read the full paper here:

Friday, 12 May 2017


Chronic Lyme Disease: A Working Case Definition

Stricker RB* and Fesler MC International Lyme & Associated Diseases Society, Bethesda, MD; Union Square Medical Associates, San Francisco, CA, USA *Corresponding author: Raphael B. Stricker, Union Square Medical Associates, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA Received: April 07, 2017; Accepted: April 25, 2017; Published: May 03, 2017

Although Lyme disease is the most common tickborne illness in the USA and Eurasia, the pathophysiology and clinical course of chronic Lyme disease (CLD) have not been formally defined. The purpose of this paper is to present a working case definition of CLD based on analysis of more than 700 peerreviewed publications. According to this definition, CLD is a multisystem illness with diverse musculoskeletal, neuropsychiatric and/or cardiovascular manifestations that result from ongoing infection with pathogenic members of the Borrelia spirochete complex often associated with other tickborne disease (TBD) pathogens. To qualify for the diagnosis of CLD, patients must have Lymecompatible symptoms and signs that are either consistently or variably present for six or more months. Two subcategories of CLD include untreated chronic Lyme disease (CLD-U) and chronic Lyme disease following a limited course of antibiotic treatment (CLD-T). The symptom patterns and optimal therapy of CLD require further study

There is some important information in this study which is available as pdf from the link above.
These are some short extracts that I find helpful. Anyone interested though should go to the full pdf to read further details.

Categories of CLD Untreated chronic Lyme disease (CLD-U) Patients whose exposure was not clearly identified and thus have prolonged untreated infection.

Chronic Lyme disease following limited antibiotic treatment (CLD-T) Patients who were diagnosed with Lyme disease and completed a limited course of antibiotic therapy, but whose symptoms persist.

This category differs from “Post-Treatment Lyme Disease Syndrome” (PTLDS), a research case definition proposed by the Infectious Diseases Society of America (IDSA) that excludes ongoing TBD infection as the cause of persistent CLD symptoms.

Clinical Judgment Until technological advances provide reliably sensitive and  specific diagnostics, some patients will continue to have a diagnosis that remains unclear. Under these circumstances, the value of clinical judgment will remain an important component in treating these individuals. According to the American Medical Association Code of Medical Ethics, the primary responsibilities of clinical medicine are to alleviate patient suffering and prevent disease [155]. As previously described by Johnson et al [149] and Cameron et al [156,157]. patients with CLD are often quite ill, and physicians are charged with finding balanced and effective management strategies for such patients.
Uncertainty about a CLD diagnosis may confound clinical decision making, but clinical uncertainty should not exclude that diagnosis. This process involves both inclusionary and exclusionary criteria. Patient care is dynamic, and clinical judgment requires vigilance in assessing clinical outcomes. As described by Kienle and Kiene, “Clinical judgment is a central element of the medical profession, essential for the performance of the doctor” [158]. Thus given the current absence of a “gold standard” test for Lyme disease, it is essential that healthcare providers should consider this condition if symptoms and/or clinical signs occur in patients with a history consistent with CLD, as summarized in the guidelines of the International Lyme and Associated Diseases Society (ILADS) [5].

Conclusions This is the first study that provides a working case definition of chronic Lyme disease (CLD) and its subcategories. We propose that CLD is the result of persistent, active infection by pathogenic members of the Borrelia spirochete complex often associated with other TBD pathogens.

Thanks to PRweb which first alerted me to this paper

Interesting comments on this paper can be found :-

Monday, 8 May 2017


Dr. Al Miller Lyme Disease Intro
Differential Diagnosis of Lyme & Borreliosis

Published on Apr 19, 2017
This is the introduction to my 4 part series on Lyme Disease.

For more information contact me at

The above was shared by a friend Dana Parish with the following information -'Iwas surprised and delighted to receive a call from retired Mayo Clinic rheumatologist, Dr. Alfred Miller, last week. He wanted to tell me about his daughter-in-law, also named Dana, who was struck by ALS at age 43. He could not imagine this happening to this beautiful, healthy woman and started investigating. 

Upon researching, he discovered links between Lyme and ALS and had her tested. WHAT DO YOU KNOW!!! She was POSITIVE! Remember, though, he had her tested at a proper lab, IGeneX, and NOT Quest or Lab Corp, which miss approx 50% of cases!

So, all the "best" doctors in the world sent her home to die with no hope and no proper investigation into the CAUSE of her ALS. Those of us in the Lyme community are well aware that the Mayo Clinic is the LAST place you want to go if you have Lyme.

Dr. Miller began treating her aggressively with IV antibiotics and they halted the progression of her illness. This does not happen with "real" ALS. 

He began contacting his patients who he had previously diagnosed with Fibromyalgia, Rheumatoid arthritis, and other inflammatory "auto-immune" arthritis and diseases and urged them to get properly assessed for Lyme and other tick-borne diseases known to cause these symptoms, like Bartonella. 

WHAT DO YOU KNOW!! Most of them had Lyme!!

I look forward to bringing you more from Dr. Miller soon. In the meantime, he is on a mission to educate doctors and patients about the ravages of this disease and his horror at the medical community's ignorance about it.

All Dr Miller's presentations are available on You Tube  

Thank you Dr Miller for having an open mind, after a lifetime in Rheumatology you were still willing to learn and seek out answers, but more importantly thank you for speaking up and sharing your experiences.

Singer/songwriter Dana Parish was involved in the recent Fox5NY News 
LYME & REASON which I posted about 

Thrilled to share that FOX 5 / Lyme and Reason Special won the Emmy for Best Science/ Health program, as presented by Dr. Oz.

Saturday, 4 March 2017


Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi in vitro

Jie FengShuo ZHANGWanliang ShiYING ZHANG


Published on Nov 22, 2016
The entire interview conducted for Lyme & Reason 2.0

I had not seen this full interview before which is especially interesting in that his team are researching a compound to work on the dormant phase of Borrelia. It is already FDA approved for use in another field. They are currently doing mouse studies and hope to lead to further human studies.
This work is due to be published in six months he says.
Thanks to Fox 5 NY for their in depth coverage of Lyme and Reason I posted earlier with links  

Fox5NY has been nominated for 3 Emmy awards

Fox5NY are already the winners in the hearts of many thousands of Lyme patients the World over for bringing our plight into the limelight and public consciousness.

 earlier videos of prof Kim Lewis

Friday, 17 February 2017


Ticking Lyme Bomb in Canada. YOU are at RISK. Sign now!

Lyme disease is one of the fastest spreading infectious diseases in the world.

Please sign this petition by March 1, 2017 asking the Canadian Government to reject the current draft Action Plan (Framework) for Lyme disease and FIX IT.

 The Framework must recognize the seriousness of this disease for all of us.

 Time is ticking. Canada has NO Plan.

Sunday, 5 February 2017


Lyme disease, or Lyme borreliosis, in North America is a group of systemic infections which may be caused by Borrelia burgdorferi sensu lato (including B. mayonii) [2], B. miyamotoi [3-5], and other unnamed tick-borne borrelia strains [3, 6]. Currently the diagnosis of emerging or reemerging infectious diseases largely depends on finding evidence of the causative agents, including borrelia, in the host by nucleic acid-based tests [7]. The accuracy of any diagnostic tests must be measured against this standard of microbiological diagnosis. Using a serologic test kit developed for the detection of antibodies against the epitopes of B. burgdorferi sensu stricto strain B31 will fail to diagnose most Lyme borreliosis patients in the first two weeks of acute infection and probably all clinical Lyme borreliosis cases caused by a strain of borrelia other than B. burgdorferi sensu stricto B31 at any stages of the disease. The inherent inaccuracy of serologic tests for Lyme disease can be compared with that of the Widal test for the diagnosis of typhoid or paratyphoid fever (Salmonella infections). A comment extracted from a Centers for Disease Control and Prevention (CDC) document is copied as follows [8]. “The Widal test is unreliable but is widely used in developing countries because of its low cost. It is a serologic assay for IgM and IgG to the O and H antigens of Salmonella Typhi, but is not specific and false positives may occur. Acute- and convalescent-phase titers are more sensitive than a single serum sample. Newer serologic assays for Salmonella Typhi infection are occasionally used in outbreak situations, and are somewhat more sensitive and specific than the Widal test, but are not an adequate substitute for blood, stool, or bone marrow culture.” 

The above is an extract from Sin Hang Lee, F.R.C.P.(C) Director, Milford Molecular Diagnostics Laboratory comments on a recent published article - “The Accuracy of Diagnostic Tests for Lyme Disease in Humans, A Systematic Review and Meta-Analysis of North American Research” by Lisa A. Waddell and colleagues

My earlier post also refers to this, which was discussed by Mary Beth Pfeiffer investigative journalist in a Huffington post article

Dr Lee's detailed comments can be read in full at

Dr Lee finishes his comments by saying :-

To overcome the low sensitivity of LD diagnostic tests in patients with early LD at the spirochetemic stage, we must first acknowledge a need to develop direct detection tests for Borrelia burgdorferi and related borrelia species known to cause Lyme borreliosis in North America. To survey the existent useful direct detection tests which may not have been published due to global editorial censorship by the mainstream medical journals, it is recommended that blind-coded simulated blood samples spiked with various species of known borreliae or blank be distributed by government regulatory agencies to all clinical laboratories performing Lyme disease testing for a bacteriology proficiency survey, as routinely conducted by the College of American Pathologists for Neisseria gonorrhoeae. The laboratories which return the correct answers would be invited to further develop a generally accepted diagnostic protocol to be used by hospital laboratories located in Lyme disease-endemic areas. To be of use for timely patient care, the results must be generated within 5 working days, preferably in 48 hours. I believe this technology is already available. The first step to the Lyme disease solution is to cut out the tribalism among the scientists whose careers were built on Lyme disease research.