Friday, 18 July 2014

BORRELIA MIYAMOTOI FOUND IN TICKS IN ENGLAND

Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England.

Link to the paper on Pubmed here  

 2014 Jul 14:1-9. [Epub ahead of print]

Borrelia miyamotoi in host-seeking Ixodes ricinus ticks in England.

Abstract

SUMMARY This paper reports the first detection of Borrelia miyamotoi in UK Ixodes ricinus ticks. It also reports on the presence and infection rates of I. ricinus for a number of other tick-borne pathogens of public health importance. Ticks from seven regions in southern England were screened for B. miyamotoi, Borrelia burgdorferi sensu lato (s.l.), Anaplasma phagocytophilum and Neoehrlichia mikurensis using qPCR. A total of 954 I. ricinus ticks were tested, 40 were positive for B. burgdorferi s.l., 22 positive for A. phagocytophilum and three positive for B. miyamotoi, with no N. mikurensis detected. The three positive B. miyamotoi ticks came from three geographically distinct areas, suggesting a widespread distribution, and from two separate years, suggesting some degree of endemicity. Understanding the prevalence of Borrelia and other tick-borne pathogens in ticks is crucial for locating high-risk areas of disease transmission.
PMID:
 
25017971
 
[PubMed - as supplied by publisher] 
  

Borrelia miyamotoi found in ticks in England is of significant importance because of problems over testing

Lyme Disease Action  discusses Borrelia Miyamotoi in this article here 

Illness following Tick bites may not always be identified by blood tests, essentially 
doctors may have to make a clinical diagnosis and treat empirically 

An excellent source of information for clinicians and patients is Lyme Disease Action 

5 comments:

  1. 'Although blood tests for Lyme disease will not detect infection with the B. miyamotoibacterium, antibiotic treatment should be the same as for Lyme disease, Krause said.'

    http://news.yale.edu/2013/01/16/so-new-it-doesn-t-have-name-yale-researchers-discover-tick-borne-infection

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  2. Perhaps ELISA in Europe may pick up some
    ELISA
    Serum samples collected at the time of admission and 1–2 weeks later were tested for anti-borrelial IgM and IgG. Serologic evidence of exposure to borreliae was detected by ELISA EUROIMMUN EI 2132–9601 M and EI 2132–9601–2 G (EUROIMMUN AG, L├╝beck, Germany). The ELISA consisted of a mixture of whole antigens from B. afzelii, B. burgdorferi, and B. garinii and thus could detect but not discriminate specific antibody against any of these species. Seroconversion in patients infected with the relapsing fever borrelia B. persica also has been detected by EUROIMMUN assay (18). Serum from mostB. miyamotoi–positive patients reacted to the antigen(s) in this assay. Anti-TBE IgM was detected by the semiquantitative EUROIMMUN ELISA EI 2661–9601 M.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310649/

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  3. [Clinical presentation of "new" tick-borne borreliosis caused by Borrelia miyamotoi].
    [Article in Russian]
    Sarksyan DS, Platonov AE, Karan LS, Malinin IE, Khalitova LI, Shakhov VI, Dudarev MV, Malinin OV, Maleev VV.
    Abstract
    AIM:
    The objective of this study was to confirm the role of B. miyamotoi in the etiology of ITBB-WOEM in Udmurtia and to investigate in detail the clinical presentation of this "new" disease.

    MATERIALS AND METHODS:
    50 adult patients with ITBB-WOEM treated in Republic Hospital for Infectious Diseases, Udmurtia, in 2010-2011 had PCR-confirmed infection by B. miyamotoi. The laboratory evidence of co-infection by other pathogens, including tick-borne encephalitis virus, B. burgdorferi sensu lato, A. phagocytophilum, E. chaffeensis, and E. muris, were absent.

    RESULTS:
    All patients had a tick bite from 10 to 18 days before the acute disease onset. The main clinical signs were high fever, fatigue, headache, chill, and sweat. Clinical, biochemical, and instrumental investigations also showed the signs of functional impairment of various organs: the liver (in about half of the patients), kidney (in 10 patients), heart (6 patients), etc. In contrast, acute ITBB with erythema migrans was usually a localized infection without a pronounced intoxication syndrome and impairments of the organs.

    CONCLUSION:
    ITBB-WOEM caused by B. miyamotoi is a systemic disease that is clinically closer to relapsing fevers transmitted by argasid ticks than to Lyme borreliosis. The number of B. miyamotoi infections in Russia may be comparable with that of Lyme disease cases, so the investigations of epidemiology, clinical presentation and therapy of this "new" disease are urgently requested.
    http://www.ncbi.nlm.nih.gov/pubmed/23252245

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  4. Lancet. 2013 Aug 17;382(9892):658. doi: 10.1016/S0140-6736(13)61644-X.
    A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe.
    Hovius JW1, de Wever B, Sohne M, Brouwer MC, Coumou J, Wagemakers A, Oei A, Knol H, Narasimhan S, Hodiamont CJ, Jahfari S, Pals ST, Horlings HM, Fikrig E, Sprong H, van Oers MH.
    Author information
    http://www.ncbi.nlm.nih.gov/pubmed/23953389

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  5. From Twitter replies
    Ticks infected with Bm were from 3 geographically distinct areas southern England' N Forest/Dartmoor/Salisbury - further studies need to be done

    Further studies needed to check prevalence of Bm and Bb sl

    Case reports USA http://1.usa.gov/UizRh2 & NL http://1.usa.gov/1wKYNu6 More severe in immunocompromised patients

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