Early signs of Multiple Sclerosis were thought to be lesions in the white matter of the brain, new research discusses disease progression and finds that it is a process starting outside of the brain.
Multiple sclerosis (MS) may progress from the outermost layers of the brain to its deep parts, and isn’t always an “inside-out” process as previously thought, reported a new collaborative study from researchers at the Mayo Clinic and the Cleveland Clinic. The traditional understanding is that the disease begins in the white matter that forms the bulk of the brain’s inside, and extends to involve the brain’s superficial layers, the cortex. Study findings support an opposite, outside-in process: from the cerebrospinal fluid-filled subarachnoid space, that cushions the outside of the brain and the cortex, into the white matter. The new findings will guide researchers as they seek to further understand and treat the disease. The study was published in the December 8th, 20011 issue of the New England Journal of Medicine.
Link to these research findings here
It says 'the early lesions were highly inflammatory'
It has been recognised for some time that some MS cases can be caused by infections such as Chamydia Pneumonia websites here and here
and Lyme Disease.
Microbiologist Thomas Grier has lectured extensively on Lyme disease and Multiple Sclerosis, links to several of his lectures are posted in the right hand column of this blog.
Below was Tom's response to the new MS research :-