Friday 21 September 2012

RAPID TRANSMISSION OF INFECTIONS FROM A TICK BITE

Regurgitation Transmission of Borrelia burgdorferi to humans ; The Rapid pathway
as contrasted with Salivary gland transmision ( the Slow pathway)

Ticks and Tickborne Bacterial Diseases in Humans: An Emerging Infectious Threat

Ticks are currently considered to be second only to mosquitoes as vectors of human infectious diseases in the world

Clinical Infectious Diseases Year 2001 vol 32: 897-928
(an Official publication of the Infectiious Disease Society of America) link here

An ongoing debate in the Lyme community is over how long it can take to be infected by a tick. I read an interesting post by Dr Alan MacDonald on the subject on the Lymenet Europe forum which I share.

'Salivary gland processing of Bb is an accepted pathway to transmission of infection to the mammallian host.
The Minimal Infective Dose ( Minimal Infective number) of properly conditioned Bb
from an infected tick is not known with certainty, although estimates or outright guessing of
Minimal tick attachment time for tranmission of infection are bandied about in the literature.

Overlooked in Tick transmission of infection to mammalian hosts is Regurgitation Transmission.

Regurgitation Transmission is a reallity which is discussed in the attachment.

In essence,the Rate of delivery of borrelia from tick to mammalian host via the salivary route
is slow. In Contrast, with regurgitation transmission, the rate of delivery of borrelia to the
mammalianhost is high.. A Huge bolus of ifectomes is delivered with a single episode of tick vomitus.

Regurgitation transmission explains cases of Erythema migrans which develop rapidly,
even those cases of EMgreater than 5cm diameter noted with the tick still attached to the center of the EM lesion.

Walter Reed's collegues solved the mystery of Yellow Fever transmission in Cuba
by "sticking out his arm" and allowing the mosquitos to feed.

If there is commentator confidence that short term attachment produces no human Bb infections
then let those experts "stick out their arm" and allow the Infected Ixodid nymphs to feed .

Food for thought...stand behind your expert statements....by stickingout your arm.'

Thank you Dr MacDonald

There is not much humor involved with reading about patients chronically ill with this disease but a mental picture of some of the most ardent deniers of Chronic Lyme Disease standing in line 'sticking out their arms' amused me today. Of course these deniers of Chronic Lyme Disease know far more than they let on about the complexity of this disease to do anything so fool hardy, as a trawl through patent applications will soon confirm. here

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Lyme Life written in 2009

I started suffering with arthritis in mainly my large joints especially my knees 6 years ago. The symptoms varied and I remember saying that every joint was affected except my elbows to one doctor. I was told it would be hormonal and to take the usual supplements cod liver oil or glucosamine ( I would certainly recommend buying shares in the companies producing these supplements) They had no noticeable affect.

All my symptoms deteriorated significantly over a few weeks,4 years ago. Hips shoulders and knees being the worst and I started with muscle weakness in upper arms and upper legs. I had difficulty standing and walking across a room. I was unable to walk upstairs and my husband was making plans to convert to a downstairs bedroom. I had seen 5 doctors and 3 Rheumatologists and put on steroids for Poly Myalgia Rheumatica diagnosis. I had been diagnosed with Fibromyalgia and ME/CFS.

I have X rays and scans showing signs of osteoarthritis and Rheumatoid arthritis. ( later note.- the X rays done some years into treatment showed my hands completely normal no signs of inflammation or RA confirming how they felt - normal) I have been retired early from the Civil Service having lost my job not to mention my earning potential. My illness seemed to progress through my body not affecting the same joints left to right at the same time. I had bursitis in left hip, right hip, left elbow. I had synovial thickening in both wrists. At that time I could not lift and hold a magazine so lifting a kettle I could only do if a third full and with two hands. Each joint in my hands fingers feet and toes were affected. I had swallowing difficulties and many other symptoms. None of this describes the endless and awful pain whenever I moved or the tiredness but inability to get quality sleep.

Two years ago my GP gave me Amoxicilin for a sinus/throat/chest infection. All my arthritis symptoms improved. The course ended the symptoms deteriorated I started a second course the symptoms improved. The improvement was more significant than when I had started taking steroids. This led my GP to suspect Lyme Disease. I laughed because we do not travel abroad but she said they had had other cases in the surgery in the early stages of tick bite and Erythma Migrans rash. She said but you have not had a bite. I said oh yes I have I had two on my ankles with rashes, March 05 this was confirmed on her computer when I had seen a locum doctor. My worst symptoms were waking up feeling rigid and having to painfully flex every joint in my body before struggling to get up. The only other time I had experienced this was in May 2003 during a flu like illness like no other I had ever experienced. At that time I had a bite and similar rash on my right foot which lasted like the other rashes about four weeks. I had also consulted the surgery and it was dismissed as a virus. I walked our dog daily in the woods adjacent to our house where the deer roam, prime tick area. Thus started my very lengthy search about Lyme Disease leading me through Lyme Disease Action to a doctor who specialises in this illness. He confirmed my GP's suspicions. I never had a positive blood test but then they are antigen tests and there is much research that shows they are unreliable. In my case the year of steroids and many weeks antibiotics could have affected the results. So with a clinical diagnosis and following ILADS International Lyme and Associated Disease Society guidelines I continued on antibiotics for two years. Both my doctors continued to treat me despite of Health Protection Agency advising against long term antibiotics. I am now nearly 100% recovered I have no pain or muscle weakness. I can walk upstairs something I could not do for three and a half years. I can garden do house work and live a normal life. I still need to pace myself and with only a few months to 60 will not be looking to return to work. Life is such a joy. Sadly there is much controversy about Lyme Disease and doctors in UK are taught that it is so rare. Well where I live in Guildford I have been in contact with a dozen other people with it so perhaps not so rare as HPA would like us to believe. I am in touch with nearly 2000 other patients through a chat line Eurolyme most had been misdiagnosed with several other illnesses. Look at UK charity Lyme Disease Action if you want to read more about this illness. There are many MP's taking an interest in the problems surrounding diagnosis and treatment see above charity links into a recent meeting at the House of Commons.

Thank goodness there are some thinking doctors around who have courageously treated me against opposition and I have made such a miraculous recovery albeit rather a lengthy one. One day there will be many more people who are helped with their chronic illnesses when IDSA starts taking note of what our courageous LLMD’s are doing following ILADS Guidelines.

ME/CFS, Fibromyalgia, Poly Myalgia Rheumatica, Arthritis, Bell’s Palsy, MS,MN, ALS, Parkinson’s, Alzheimer’s, Heart Block, Stroke, Psychiatric, gastric problems the list is endless. Not all suffering from Lyme Borrelia but how many are even properly assessed for it.

UPDATE

UPDATE 10 January 2012

LOOKING AT LYME DISEASE - MSIDS

Friday 21 September 2012

RAPID TRANSMISSION OF INFECTIONS FROM A TICK BITE

Ticks and Tickborne Bacterial Diseases in Humans: An Emerging Infectious Threat

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