Thursday, 3 October 2013
BORRELIA BURGDORFERI (LYME DISEASE) BIOFILM
From Dr Alan MacDonald -
Borrelia biofilms are now proven to constitute expressions of Human disease in multiple sites:
Skin: Borrelia lymphocytoma, Heart Valve: borrelia Endocarditis, Bone: borrelia Osteomyelitis
In the Ixodid tick gut: biofilms of Borrelia are established and provide a survival mechanism for the
infectomes of Borrelia between the Blood meals which provide the Only nutrition to the Borrelia.
Blood meals taken by a tick may be spaced at one year intervals.
Biofilms of borrelia are Communities. Within each biofilm Community there is microbe Specialization.
Shape shifting of borrelia between spiral, to cystic, to granualr borrelia is confirmed my microscopic
inspection of Living borrelia biofilm communities and corroborates the Specialization of individual
borrelia because of obvious differences in Shape. Biochemical specialization, quorum sensing, quorum Quenching, lateral DNA transfers between members of the biofilm community [horizontal DNA Transfer]
production of self-generated extrcellular matrix materials [ Outer surface sloughed proteins,
and extrusion of DNA into the Matrix ( extracellualr DNA [eDNA]) :: These are all in play in Borrelia biofilms.
Biofilm infections are ALWAYS CHRONIC INFECTIONS.
Biofilm infections are Never Cured by simple short course Antibiotic Therapies.
Please follow the link ( You Tube above) to view the Borrelia biofilms from the Laboratory of Dr Eva Sapi, University of New Haven,
West Haven , Connecdticut. The video is in High Definition , with a resolution of 1080dpi, so the images on
your computer screen are fully equal to the images as seen through the microscope. The "green glow" in the images is due to the insertion of Green fluorescent Protein (GFP) into borrelia burgdorferi to enable sharp contrast between
individual biofilm community members and the intervening extracellular matrix investment material