Friday, 31 August 2012

LYME DISEASE: A COMPREHENSIVE APPROACH TO AN EVOLVING THREAT


Full Committee Field Hearing - Lyme Disease: A Comprehensive Approach to an Evolving Threat


US SENATE HEARING here 



Amiram Katz, MD – Written Testimony

Lyme disease is a continued and escalating public health issue.

A major problem in assessing the magnitude of this serious public health issue is the undiagnosed cases.

 The Diagnosis and Treatment of Chronic Lyme disease (AKA: post treatment Lyme disease)

It is clear that more accurate tests are needed and more so, a test that will tell us if the infection is active.

What are the possible explanations of developing “chronic” Lyme disease?

Persistent Lyme infection. In spite of the IDSA’s treatment recommendations stating that two weeks (range 10 – 21 days) of oral antibiotics (doxycycline, amoxicillin, or cefuroxime), are sufficient to treat Lyme disease diagnosed by ECM (Bull‘s eyerash, there is culture supported data, suggesting otherwise

Persistent presence of non infective Lyme spirochetes after adequate antibiotic treatment leading to an ongoing disease.

Persistent/ untreated infection of other tick borne agents, transmitted by the same ticks (“co-infections”)

Re infection. Living in a Lyme endemic area, where about 50% of the tick bites go undetected, unnoticed re-infection can result in a “chronic” picture. This includes the “co-infections”.

Treatment

When facing “chronic” Lyme, with an autoimmune flavor, one should consider treatment with a combination of hydroxy chloroquine and a macrolide.

Saturday, 25 August 2012

WHEN THE DOCTOR GETS SICK - THEY GET IT

A recent discussion on Eurolyme was about when a doctor or their loved one gets sick with Chronic Lyme Disease - it seems that only then is a paradigm shift in how they view the disease.

I have heard the comment a number of times : 'You don't get Chronic Lyme until you get Chronic Lyme' so true.

A recent response in the BMJ from  a Doctor was highlighted on the Lyme Disease Action website here 

'What have i learnt? I have learnt to take a good travel history and that guidelines are just that - guidelines, and not always applicable to every patient and that clinical assessment is just as important'.Caroline J Rayment, GP partner.

Link to the BMJ here

It was with interest I read the following presentation from the Lyme Disease Action conference 2012  here  


The Neuropsychiatry of Lyme disease: Case presentation
Dr Sandra Pearson, MB ChB, MRCPsych Consultant Psychiatrist and Medical Director www.LymeDiseaseAction.org.uk Link here 

There are a growing number of doctors that have been touched by Lyme but even so their colleagues are slow to pay attention, I remember one doctor saying that despite the number of doctors and consultants they were in touch with they had to travel to US from UK to get appropriate treatment.

How sad that medicine is such a slow grinding process even when innovative treatments are proving successful.

Hopefully with more awareness of Lyme Disease people will seek early medical treatment and avoid a chronic illness developing. 


In the meantime there will be a few more thousand patients to every Doctor that gets sick with Chronic Lyme Disease so here's hoping doctors start listening to all the available research sooner rather than later and realise as  Caroline Rayment points out 'guidelines are just that - guidelines, and not always applicable to every patient and that clinical assessment is just as important'


Tuesday, 21 August 2012

PATHOLOGY NEEDED TO SHOW PERSISTENCE OF BORRELIA

Below is an extract from BettyG's Blog written by Tom Grier - to read the whole posting click here 

'The experts got almost everything important about Lyme disease wrong from the very beginning, and never once tried to apologize or correct their mistakes. 

 So I ask again: Why do we call them Lyme experts? 

They should be held accountable for mistakes that either came from arrogance, incompetence, or a purposeful choice to mislead us.

Personally I believe it to be all three. 

But I am not asking anyone to just accept my arguments based on history or my opinions.

I am asking the entire world to base an opinion on the basis of pathology. 

Scientists must look for the persistence of Borrelia species in the human brain after antibiotic treatment. 

A study should include no less than 1000 human brain autopsies world-wide on Lyme patients, dementia patients and MS patients. 

We need to use state of the art research tools to look for the survival of the bacteria in the human brain. 

We must use at minimum the following tools: 

Fluorescent-antibody stains for Borrelia, Silver-Stains, RNA-PCR for a generic Borrelia markers that are not species specific, but can detect any Borrelia species, thin section microscopy, the Bosner-Steiner method of staining and brain tissue analysis (this allows many cell layers to be analyzed instead of just one) tissue culture, 
PCR and antigen captures tests of Borrelia antigens. 
And for heavens sake: don't let the old school "Lyme-Experts" have a cent of the research monies to do this study; 
keep the CDC out of it, 
and don't allow corporate health organizations to contribute funding. 
Use private monies that are untainted by conflicts of interest.' 

Tom Grier

There are more interesting lectures by Tom Grier posted in the right hand column of Looking at Lyme Disease blog.

Thursday, 16 August 2012

LYME DISEASE CHALLENGES

Well done to Voice America for this radio interview :- 

Lyme Disease Challenges for Family Caregivers and Family Members

An excellent  interview on Family Care givers unite - click here


 Jim Wilson, President and founder of the Canadian Lyme Disease Foundation, is himself a victim of Lyme disease and the father of victims of Lyme disease. Janet Sperling is a trained entomologist whose 15 year-old son fell desperately ill. After months without a clear diagnosis, she and her husband confronted the possibility of Lyme disease. Jim and Janet discuss the serious challenges that Lyme disease creates for children, adults, family caregivers and families. They describe most important things that family caregivers, families, and family members should know about the disease, and where they can they find information about services and solutions for the challenges. They discuss communications with doctors which, they stress, should involve family caregivers giving information to doctors as well as family caregivers taking the advice of doctors. They identify the responses they want to see from healthcare systems and governments and they share their messages for family caregivers.


Sunday, 12 August 2012

DO YOU HAVE SYMPTOMS THAT MIGRATE - Arthritis, Myalgias, Neuropathic pain inc tingling and numbness?

Do you have symptoms that migrate? Such as Arthritis, Myalgias, Neuropathic pain (inc tingling, numbness)

Is your pain influenced by hormonal cycle ? ( worse flairs before, during or after cycle) - sorry to the men


Is your pain resilient to 

standard treatment modifiers (NSAIDS, SSRI's, Neuroleptic mediators, Narcotics)?

Does antibiotic use increase or decrease pain (ie. Jarisch-Herxheimer reaction)  given for such as sinus or UTI infections ?

Is you pain associated with multi-systemic symptoms?

Then you are probably looking at a Muti-Systemic Infectious Disease Syndrome - MSIDS

Watch this presentation by a leading doctor in this field Richard I. Horowitz, MD at a hearing 
hosted by Congressman Chris Gibson


 - starts at 18 mins in .




NB. RA and Lupus Rheumatoid factor correlates with antibody titres against Borrelia - Lyme Disease, something most Rheumatologist don't yet recognise.

In an earlier presentation By Dr Horowitz at the 2010 London ILADS conference DVD available through Lyme disease Action charity  Dr Horowitz mentions that Plaquenil plus  Minocycline often used in treatment for RA patients as a disease modifier regime - actually begs the question are they treating an underlying infection perhaps Lyme Disease and Mycoplasma.


I posted links to this hearing previously, Dr Horowitz presents in Part 1  here   






Watch live streaming video from skidmorevideo at livestream.com

Monday, 23 July 2012

OPTIMIZING OUR PROBIOTICS WITH DIETARY CARBOHYDRATE CHOICES TOM GRIER


Optimizing Our Probiotics With Dietary Carbohydrate Choices 

by Tom Grier 

Recently after the July floods in Hermantown, MN near Duluth,many people in the region experienced severe diarrhea, possibly from the contamination of well water.
 
None suffered from this condition more so than our singer in our band. 


For over a week she took her probiotic capsules only to find each day her condition seemed to get worse.
 
Medically trained she knew taking her probiotic with milk would give something for the Acidophillus and Bifidobacteria bacteria to grow on.
 
Unfortunately she was severely lactose and gluten intolerant and felt milk or grains would worsen her condition. 

Not knowing what else to do she adhered to the medically recommended diet for severe dysentery known as theBRATs diet.   (Bananas, Rice, Apples, Toast)
  
She felt she had few dietary choices that would help, but with a little research she soon discovered that what her diet needed wasn’t dairy products or wheat; but rather a special class of carbohydrates:
 
Specifically oligosaccharides.

Definitions: 

Oligosacharide - 3-10 simple sugars linked together and found in natural foods. 

Lactobacillus acidophilus
(Latin meaning acid-loving milk-bacterium) is an aerobicbacterium that ferments sugars into lactic acid, and grows readily at rather low/acidic pH values (below pH 5.0) and has an optimum growth temperature of around 37 °C (99 °F), and is used in the production of acidophilus-type yogurt.
(Source - Wikipedia) 

Bifidobacterium is a genus of Gram-positive, non-motileanaerobic bacteria. They are inhabitants of the gastrointestinal tract, vagina, and mouths (B. dentium) of mammals.
 
Bifidobacteria are one of the major genera of bacteria that make up the colon flora in mammals. Some bifidobacteria are used asprobiotics.
 
(Before the 1960s, Bifidobacterium species were collectively referred to as "Lactobacillus bifidus".) (Wikipedia) 

Most digestion takes place in the upper intestine where the predominant digestive bacteria is the aerobic Lactobacillus acidophillus.

These bacteria also help supply us with vitamin-K for blood clotting which our bodies cannot produce without L. acidophillus. 


In the lower-intestine/colon, anaerobic bifidobacteria finish most of the digestive processes. It is in the colon where diarrhea must be controlled. 

Why Carbohydrates are important in our GI Tract 

Not long ago we were all taught that there were just two kinds of carbohydrates: Sugars and Starches. 

Simple sugars were just one or two six carbon rings linked to each other.
Sucrose or table sugar is a disaccharide made of glucose and fructose.

      Glucose  Sucrose (Glucose + Fructose) 

Carbohydrates such as starches, were long chains of simple sugars strung together like a chain, or linked in a fashion resembling a tree branch and we called them complexed-carbohydrates. 
 
Then we were told about another class of carbs that didn’t count much because they were mostly undigestible, and we called them fibers or insoluble-fibers.
 
Later in the 1970s,  we learned that dietary fiber lowered the risk of colon cancer.
 
Then we discovered soluble-fibers, and learned that they lowered our cholesterol. 
 
As it turns out, this class of complex-carbohydrates known as dietary fiber is important to our GI health, not just because of cancer and cholesterol but because of how they are digested. 
 
The term complex-carbohydrates may becoming an obsolete term because we now know that some complex-carbs raise blood sugar faster than many sugars.
 
And many simple sugars play roles we never dreamed of beyond just giving us energy/calories. 
 
Most starches are only partially digested in the upper intestine.
 
The starches then complete the digestion process in the colon, where the break-down products play a vital role in the health of the colon.  
 
Some starches especially resistant starches are fermented in the colon and produce a fat that our body needs called short-chain-fatty-acids, SCFAs, which cannot easily be obtained in our diet.
 
 (Pretty cool huh! A carbohydrate that becomes a fat in the gut because of our probiotic anaerobic bacteria!)
 
One SCFA is butyrate which protects our colon cells from genetic damage and cancer. 

Between the simple sugars and the starches (polysaccharides),is a middle class of carbohydrates known as theoligosaccharides.
 
 Oligosaccharides are made of chains of 3-10 simple sugars and can be found naturally in many plants; they often have a slight sweetness and have been described by food scientists as having a pleasant mouth-feel, and are now common food additives for texture and fiber. 

Natural sources of oligosaccharides include:
 onions, leeks, garlic, most legumes (beans, lentils, and peas) wheat, asparagus, and chicory (labeled as inulin on food labels), and al dente pasta. 

Why are these foods good to consume with your probiotics? 

Recently this class of foods have been referred to as pre-biotics, because they feed the bacteria we need to digest our food.
 
Unfortunately Americans get about 1/3 the levels of oligosaccharides in their diet as Europeans, or what is consumed in a typical Mediterranean diet. 
 
 Because the upper intestine has a hard time breaking down this class of carbs, almost 90 % escapes to the colon where oligosaccharides reach their full pre-biotic potential. 
 
A prebiotic supports the health of probiotics! 

So now you can see how taking a probiotic does little good for your intestinal track if you don’t support the probiotic bacteria with proper nutrition. 

Up until the 21st century we used to think nutritional support of our gut bacteria was as simple as drinking a glass of milk. 

In addition to the oligosaccharides, another class of prebiotic is emerging.
 
Both resistant starches and fermentable fiber are two carbohydrates that also add to our colon’s good health.
 
You might know resistant starches by their signature sound and smell as a by product of digestion in the colon is methane gas. 
 
The digestion of fermentable fiber in the colon also produces more beneficial by-products including:
 
short-chain-fatty-acids, and some B-vitamins, and recapture dietary magnesium and calcium that would have been excreted.
 
So as we feed our probiotic bacteria with these alternative food sources we also reap the benefits of:
 
lower cholesterol, lower triglycerides, improved insulin sensitivity, and improved immune system function. 

If you have diarrhea from antibiotic use and are taking probiotic capsules or probiotic yogurts, and kefirs, then the following foods may help support the probiotics and improve the health of your intestinal tract.

Bon Appetite 

BRAT diet:  Bananas, Rice, Apples, Toast.
 
Bananas may be more effective when they are green, and use low-fiber or white bread for toast.
 
Other foods to eat during episodes of diarrhea include
 
crackers, pretzels, apricots, applesauce, mashed potatoes, noodles, cream of wheat or cream of rice, smooth peanut butter, eggs prepared any way but fried, skinless poultry, mild white fish, lean beef, low-fat cottage cheese, and canned vegetables.
 
 It is best to eat small, frequent snacks and meals instead of larger meals.
 
Beans, peas, lentils, wheat, rice (Creme of Rice hot cereal seems to work best)  
 

Foods to Avoid

* Greasy, deep-fried, fatty foods, and rich saucesbecause these may worsen diarrhea. 
 
* Sugary or very spicy foods may also be bothersome. 

* Sugar-free gums and candies usually contain sugar alcohols (sweeteners) that may cause diarrhea.  

* Large meals with large amounts of protein and Fats. 

Saturday, 21 July 2012

LYME DISEASE INCREASE IN CANADA

More in the news about Lyme disease in Canada


Janet Sperling a University of Alberta entomologist, and co-author of a submission to The Canadian Entomologist on the presence of Lyme disease ticks in Alberta, was interviewed on Alberta Prime Time link to the interview here 


A five year study is showing that Alberta is not safe from a species of tick that carries Lyme disease — news article here 


Researcher warns heavy rains increase risk of Lyme-carrying ticks across Alberta. Ticks “like it moist,” said George Chaconas, a University of Calgary professor who holds the Canada research chair in the Molecular Biology of Lyme Borreliosis. “They don’t like it dry.” here


Research published in The Canadian Entomologist

Volume 141, Number 6, November/December 2009ISSN 1918-3240

Lyme borreliosis in Canada: biological diversity and diagnostic complexity from an entomological perspective Janet L.H. Sperling and Felix A.H. Sperling



Abstract: Lyme borreliosis (LB), also known as Lyme disease, is emerging as a serious tickborne illness across Canada. More than three decades of research on LB in North America and Europe have provided a large, complex body of research involving well-documented difficulties at several levels. However, entomologists are well situated to contribute to resolving some of these challenges. The central pathogen in LB, the spirochete Borrelia burgdorferi Johnson et al., includes numerous genospecies and strains that are associated with different disease symptoms and distributions. The primary vectors of LB are ticks of various Ixodes Latreille species (Acari: Ixodida: Ixodidae), but questions linger concerning the status of a number of other arthropods that may be infected with B. burgdorferi but do not transmit it biologically. A variety of vertebrates may serve as reservoirs for LB, but differences in their ability to transmit LB are not well understood at the community level. Persistent cystic forms of and immune system evasion by B. burgdorferi contribute to extraordinary challenges in diagnosing LB. Multiple trade-offs constrain the effectiveness of assays like ELISA, Western blot, polymerase chain reaction, and microscopic visualization of the spirochetes. Consequently, opportunities abound for entomologists to contribute to documenting the diversity of the players and their interactions in this devilishly complex disease.



Janet's son featured in a TV program on Lyme Disease here note the program was in two parts.


An earlier post about a news article interviewing Janet  here